The efficacy and role of Vinorelbine

Vinorelbine is a relatively new vinca alkaloid developed by Pierre Fabre in the mid-1990s. It is a semi-synthetic derivative of vinblastine derived from a compound of the genus Vinca. a drug. It is a cell cycle-specific preparation that blocks cell activity during the middle of mitosis. Vinca alkaloids mainly bind to tubulin monomers, thereby inhibiting microtubule formation. If there are not enough microtubules, the newly duplicated chromosomes cannot be pulled apart and cell division will be blocked. Failure of cell division induces apoptosis. The particularity of Vinorelbine is that it is highly liposoluble and therefore has a complete depolymerization effect on microtubules.
Vinorelbine is a semi-synthetic vinca alkaloid with broad-spectrum anti-tumor activity and low toxicity. Cytotoxic effects are produced by interfering with the accumulation of microtubules during mitosis. For non-small cell lung cancer, breast cancer, ovarian cancer, soft tissue and visceral metastases and lymphoma.