Vindesin Sulfate production methods and functions

Vindesin Sulfate production method: Vindesin Sulfate is a vinblastine which is reacted with anhydrous hydrazine under normal pressure to form a hydrazine compound. Dissolved in THF, hydrochloric acid was added, butyl nitrite was added dropwise at 0 ° C to form an azide compound, and a solution of triphenylphosphine in THF was added. After the impurities are removed, they are neutralized with ammonia, then extracted with dichloromethane, evaporated to dryness in vacuo, and purified by column chromatography or high pressure liquid to give Vindesin Sulfate.
The role of Vindesin Sulfate: Vindesin Sulfate inhibits the formation of proliferating cell spindles, stopping cell growth in the middle of mitosis, and is a cell cycle-specific drug. For lung cancer, malignant lymphoma, breast cancer, esophageal cancer, pediatric acute lymphoblastic leukemia, chronic myelogenous leukemia, melanoma, germ cell tumor, ovarian cancer.